Role of Immunohistochemical Analysis of p16 and p53 in Vulvar Carcinoma.

Tumor human papillomavirus (HPV) status is an important prognostic factor in vulvar cancer as indicated in the latest WHO classification of female genital tract tumors. Immunohistochemical detection of p16 is well established as a surrogate biomarker for tumor HPV association, including squamous cell carcinomas of the vulva. HPV-independent vulvar carcinomas are heterogeneous with 2 subcategories according to the TP53 mutation status.

Concurrent Validity of Motion Parameters Measured With an RGB-D Camera-Based Markerless 3D Motion Tracking Method in Children and Young Adults.

Objective: Low-cost, portable RGB-D cameras with integrated motion tracking functionality enable easy-to-use 3D motion analysis without requiring expensive facilities and specialized personnel. However, the accuracy of existing systems is insufficient for most clinical applications, particularly when applied to children. In previous work, we developed an RGB-D camera-based motion tracking method and showed that it accurately captures body joint positions of children and young adults in 3D.

Water-dispersable photoreactors based on core-shell mesoporous silica particles.

Robust solid-core silica particles with submicrometer size and anthracene-containing mesoporous shell were obtained and studied as model water-dispersable photoreactors. An anthracene derivative containing a triethoxysilyl group was synthesized and co-condensed with tetraethoxysilane in various ratios to form a photoactive mesoporous shell with a thickness up to approximately 80 nm on previously prepared solid silica particles. Mesopores of as-synthesized particles, without a commonly applied removal of the micellar templates, offered a confined space for solubilization of hydrophobic molecules.

Multicomponent Synthesis of 4-Aryl-4,9-dihydro-1-pyrazolo[3,4-]quinolines Using L-Proline as a Catalyst-Does It Really Proceed?

Looking for effective synthetic methods for 1-pyrazolo[3,4-]quinolines preparation, we came across a procedure where, in a three-component reaction catalysed by L-proline, 4-aryl-4,9-dihydro-1-pyrazolo[3,4-]quinolines are formed. These compounds can be easily oxidised to a fully aromatic system, which gives hope for a synthetic method that could replace, e.g.