Publications by authors named "A L Griswold"
Introduction: Alzheimer disease (AD) plasma biomarkers are noninvasive measures of the key amyloid beta (Aβ) and tau pathologies. Validation and generalization studies are needed to fully understand their potential for AD prediction and diagnosis in the elderly population.
Methods: In 1,067 Amish individuals aged ≥ 65, we measured plasma Aβ and tau to assess their relationships with AD-related outcomes.
Background: This study aims to elucidate ancestry-specific changes to the genomic regulatory architecture in induced pluripotent stem cell (iPSC)-derived oligodendroglia, focusing on their implications for Alzheimer's disease (AD). This work addresses the lack of diversity in previous iPSC studies by including ancestries that contribute to African American (European/African) and Hispanic/Latino populations (Amerindian/African/European).
Methods: We generated 12 iPSC lines-four African, four Amerindian, and four European- from both AD patients and non-cognitively impaired individuals, with varying genotypes ( and ).
Article Synopsis
- ε4 is the most significant genetic risk factor for Alzheimer's disease (AD), with about half of AD patients having at least one ε4 allele.
- Researchers found that the African-specific A allele of rs10423769 significantly reduces the AD risk associated with ε4 homozygotes by roughly 75%.
- The protective variant is located in a specific region of chromosome 19, demonstrating differences at the structural and DNA methylation levels compared to non-protective variants, and emphasizing the need for diverse ancestry representation in AD studies.
Article Synopsis
- Epigenetic clocks measure aging rates through DNA methylation patterns and could help predict age-related diseases like Alzheimer's, but lack validation in genetically diverse groups.* -
- A study evaluated these clocks in 621 Alzheimer's patients and controls from African American, Hispanic, and white backgrounds, revealing reduced accuracy in those with mixed ancestries, particularly with substantial African heritage.* -
- The findings indicate that methylation-related genetic variations (meQTL) are more common in individuals of African ancestry, highlighting the need for improvements to make these clocks more effective across diverse populations.*
Article Synopsis
- The study investigates how cerebral amyloid angiopathy (CAA) affects recovery from ischemic stroke using a 5xFAD mouse model, hypothesizing that amyloid-beta buildup leads to worse outcomes by impairing the blood-brain barrier (BBB).
- Findings reveal that CAA worsens stroke effects, resulting in narrowed BBB microvessels, decreased cerebral blood flow, and hindered tissue recovery, alongside different gene expression patterns in endothelial cells and neural progenitor cells in the hippocampus.
- Experiments indicate that disrupting the CXCL12-PIK3C2A-CREB3L2 pathway negatively impacts neurogenesis, but activating the PI3K pathway can restore it