Analytical Validation of the Labcorp Plasma Complete Test, a Cell-Free DNA Comprehensive Genomic Profiling Tool for Precision Oncology.

To help guide treatment decisions and clinical trial matching, tumor genomic profiling is an essential precision oncology tool. Liquid biopsy, a complementary approach to tissue testing, can assess tumor-specific DNA alterations circulating in the blood. Labcorp Plasma Complete is a next-generation sequencing, cell-free DNA comprehensive genomic profiling test that identifies clinically relevant somatic variants across 521 genes in advanced and metastatic solid cancers.

Machine learning models provide modest accuracy in predicting clinical impact of porcine reproductive and respiratory syndrome type 2 in Canadian sow herds.

Objective: To determine the predictive potential of the open reading frame 5 nucleotide sequence of porcine reproductive and respiratory syndrome (PRRS) virus and the basic demographic data on the severity of the impact on selected production parameters during clinical PRRS outbreaks in Ontario sow herds.

Methods: A retrospective longitudinal study of clinical outbreaks in Ontario sow herds at various points between September 5, 2009, and February 5, 2019, was conducted using herds as units of analysis. Data were gathered from study sow farms in Ontario at the start of each clinical outbreak.

Reinterpretation of Report of Tetrataenite in Bulk Alloy Castings.

After the publication of "Direct formation of hard-magnetic tetrataenite in bulk alloy castings" Ivanov et al., Advanced Science 10 (2022) 2204315, the authors identified a potential misinterpretation of the experimental data. Further work confirms that the original conclusions cannot be supported, and accordingly the paper is retracted.

Ketamine Versus Etomidate for Rapid Sequence Intubation: A Systematic Review and Meta-Analysis of Randomized Trials.

Objectives: To compare the safety and efficacy of ketamine and etomidate as induction agents to facilitate emergent endotracheal intubation.

Data Sources: We searched MEDLINE, Embase, Cochrane Clinical Trials Register, and ClinicalTrials.gov from inception to April 3, 2024.

Titanium Surface Synergy: Strontium Incorporation and Controlled Disorder Nanotopography Optimize Osteoinduction.

Osteoporotic fractures and arthritis represent a major socioeconomic health burden. Fragility fracture fixation and joint replacement are often undertaken using titanium (Ti) or Ti alloy implants. Ideally these should induce bone formation and reduce osteoclast formation.