Publications by authors named "A L Gopinath"

Midbrain dopamine neurons are well-known to shape central nervous system function, yet there is growing evidence for their influence on the peripheral immune systems. Here we demonstrate that midbrain dopamine neurons form a circuit to the spleen via a multisynaptic pathway from the dorsal vagal complex (DVC) through the celiac ganglion. Midbrain dopamine neurons modulate the activity of D1-like and D2-like dopamine receptor-expressing DVC neurons.

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Article Synopsis
  • This study investigates how Gestational Diabetes Mellitus (GDM) is linked to negative pregnancy outcomes, comparing two sets of diagnostic criteria: the IADPSG recommendations and higher cut-off criteria.
  • A systematic review and meta-analysis of 30 observational studies were conducted, focusing on data from 2010 to 2023, using comprehensive databases for sourcing relevant studies.
  • Results showed that GDM significantly increased the likelihood of adverse maternal outcomes like cesarean section (aOR 1.24) and pregnancy-induced hypertension (aOR 1.55), as well as neonatal outcomes like macrosomia (aOR 1.38).
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The objective of this systematic review and meta-analysis was to evaluate the efficacy and long-term outcomes of arthroscopic meniscus repair, focusing on success, failure, and reoperation rates. A comprehensive literature search was conducted across PubMed, EMBASE, Cochrane Library, and Scopus, including studies that involved patients undergoing arthroscopic meniscus repair with a minimum follow-up of two years. The quality of the included studies was assessed using the Cochrane Risk of Bias Tool for randomized controlled trials and the Newcastle-Ottawa Scale for observational studies.

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Many animal cells that crawl on extracellular substrates exhibit durotaxis, i.e., directed migration toward stiffer substrate regions.

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This study focuses on the distribution of some selected organochlorine pesticides and emerging contaminants within the surface sediments of an Arctic fjord, Kongsfjorden and nearby lakes. Organochlorine pesticides (OCPs) such as dicloran, p,p'-DDT, p,p'-DDE, p,p'-DDD were studied along with five emerging contaminants namely diuron, chlorpyrifos, dicofol, pendimethalin and bifenthrin. The highest values of OCPs recorded among the fjord and lake environments during the time of study was 0.

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