Publications by authors named "A L Fuller"
The T cell antigen presentation platform MR1 consists of 6 allomorphs in humans that differ by no more than 5 amino acids. The principal function of this highly conserved molecule involves presenting microbial metabolites to the abundant mucosal-associated invariant T (MAIT) cell subset. Recent developments suggest that the role of MR1 extends to presenting antigens from cancer cells, a function dependent on the K43 residue in the MR1 antigen binding cleft.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the optimal timing for surgery after traumatic brain injury (TBI) and its effect on inflammatory cytokine levels.
- It involved 82 TBI patients with depressed skull fractures, analyzing pre-and postoperative serum samples using a specialized assay to measure cytokine levels.
- Results indicated that surgeries performed after 48 hours post-injury were associated with significantly higher TNF-α levels, while factors like post-traumatic seizures and neurological deficits influenced cytokine responses.
Background: Epilepsy is a chronic condition that confers social stigma, reduced engagement in work and social activities, increased risks of comorbidities, and premature death. It is often treated with medications, but in about a third of patients, epilepsy may be refractory to medications. It is estimated that each year 211,456 new individuals across Africa meet criteria for surgically treatable epilepsy, and the current volume of surgically treatable epilepsy is 1,819,067 cases across the region.
View Article and Find Full Text PDFObjective: The Endoscopic Third Ventriculostomy Success Score (ETVSS) is a useful decision-making heuristic when considering the probability of surgical success, defined traditionally as no repeat cerebrospinal fluid diversion surgery needed within 6 months. Nonetheless, the performance of the logistic regression (LR) model in the original 2009 study was modest, with an area under the receiver operating characteristic curve (AUROC) of 0.68.
View Article and Find Full Text PDF