Publications by authors named "A L Francis"
Ecologic and economic motives for transforming calcium-based food wastes into sustainable value-added products: a review.
Environ Sci Pollut Res Int
December 2024
An overview of various industrial and bio-applications of unavoidable bio-waste materials reported in the literature over the last 25 years is presented in this review. Calcium-based food wastes or "unavoidable bio-wastes" are hybrid bio-composite materials, consisting of a softer organic matrix surrounding a stiff mineralized ceramic phase. A wide range of different bio-wastes that are already in use or are investigated for multipurpose applications are presented.
View Article and Find Full Text PDFUnlabelled: Lenacapavir (LEN) is a highly potent, long-acting antiretroviral medication for treating people infected with muti-drug-resistant HIV-1 phenotypes. The inhibitor targets multifaceted functions of the viral capsid protein (CA) during HIV-1 replication. Previous studies have mainly focused on elucidating LEN's mode of action during viral ingress.
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- The study investigates how clinical attacks contribute to ongoing disability in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD).
- A total of 165 patients were analyzed using disability scores recorded after at least six months post-attack, with findings showing a significant increase in disability scores correlating with the number and type of relapses.
- Results indicated that specific relapse types, particularly the combination of transverse myelitis and optic neuritis, had the most substantial impact on increasing residual disability.
Article Synopsis
- Clean and abundant water is vital for the health, ecosystems, and economy of New York State.
- Climate change poses serious challenges to the quality and quantity of surface and groundwater, affecting drinking water and wastewater management.
- The Water Resources chapter focuses on these challenges and offers strategies for New Yorkers to adapt and enhance resilience in the face of climate change.
Unlabelled: Lenacapavir (LEN) is the first in class viral capsid protein (CA) targeting antiretroviral for treating multi-drug-resistant HIV-1 infection. Clinical trials and cell culture experiments have identified resistance associated mutations (RAMs) in the vicinity of the hydrophobic CA pocket targeted by LEN. The M66I substitution conferred by far the highest level of resistance to the inhibitor compared to other RAMs.
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