OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival.

Cancer cells often display centrosome amplification, requiring the kinesin KIFC1/HSET for centrosome clustering to prevent multipolar spindles and cell death. In parallel siRNA screens of deubiquitinase enzymes, we identify OTUD6B as a positive regulator of KIFC1 expression that is required for centrosome clustering in triple-negative breast cancer (TNBC) cells. OTUD6B can localise to centrosomes and the mitotic spindle and interacts with KIFC1.

In-silico evaluation of the effect of set-up errors on dose delivery during mouse irradiations with a Cs-137 cell irradiator-based collimator system.

Set-up errors are a problem for pre-clinical irradiators that lack imaging capabilities. The aim of this study was to investigate the impact of the potential set-up errors on the dose distribution for a mouse with a xenographic tumour irradiated with a standard Cs-137 cell irradiator equipped with an in-house lead collimator with 10 mm diameter apertures. The EGSnrc Monte-Carlo (MC) code was used to simulate the potential errors caused by displacements of the mouse in the irradiation setup.

Australian general practice registrars' billing patterns: a cross-sectional analysis from the Registrars Clinical Encounters in Training (ReCEnT) study.

Background: In Australia, a government insurance scheme (Medicare) pays set rebates for a range of distinct general practitioner (GP) services. GPs may 'bulk-bill' and accept the Medicare rebate fee directly, or 'privately-bill' by charging the patient a higher fee that is partially reimbursed by Medicare. The billing behaviour of Australian GP registrars (trainees) and their decision to bulk- or privately-bill patients is an evidence gap.

A radiation therapy platform to enable upright cone beam computed tomography and future upright treatment on existing photon therapy machines.

Background: The conventional lying down position for radiation therapy can be challenging for patients due to pain, swallowing or breathing issues. To provide an alternative upright treatment position for these patients, we have developed a portable rotating radiation therapy platform which integrates with conventional photon treatment machines. The device enables cone-beam computed tomography (CBCT) imaging of patients in an upright position, and the future delivery of therapeutic radiation.

Adapting the design of the ongoing RAMPART trial in response to external evidence: An example for trials which take many years to run and report.

Clinical trials to establish the efficacy of new agents in the adjuvant cancer setting typically take many years to complete. During that time, external factors can impact recruitment and reporting plans. An example is a new standard of care becoming available during the recruitment period.