Publications by authors named "A L Fauchais"
Objective: Recently, three distinct phenotypes of Sjögren's disease (SjD) patients have been described, based on cluster analysis: B-cell active with low symptoms (BALS), high systemic activity (HSA), and low systemic activity with high symptoms (LSAHS). We aimed to assess whether these clusters were associated with distinct biomarkers and the prognostic value of IFN signature.
Methods: The ASSESS cohort is a 20-year prospective cohort of SjD patients.
Background And Aims: Systemic sclerosis (SSc) is an autoimmune connective disease characterised by excessive extracellular matrix deposition and widespread skin and internal organ fibrosis including various cardiac manifestations. Heart involvement is one of the leading causes of death among patients with SSc. In this study, we aimed to assess the effect of various vasodilator treatments.
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- * It typically affects Caucasians equally across genders and can also be associated with other autoimmune diseases like polyarteritis nodosa.
- * While ocular symptoms often have a good prognosis with potential recovery of vision, cochleo-vestibular issues can lead to serious and irreversible hearing loss, and treatment options are not well-established due to the condition's rarity.
Objectives: Giant cell arteritis (GCA) often features upper respiratory tract (URT) and orofacial manifestations, which signal the involvement of external carotid artery branches. In this study, we aimed to describe the frequency of various URT/orofacial symptoms at GCA onset, as well as the main characteristics of patients presenting these symptoms.
Methods: We included all patients who were newly diagnosed with GCA between 1976 and April 2022 at the Internal Medicine Department of a tertiary-care hospital.
Article Synopsis
- - The study focused on recurrent fever of unknown origin (FUO), a rare condition, analyzing data from 170 patients over 23 years to understand diagnostic challenges and outcomes.
- - Key findings showed that older age (≥ 65), specific medical history, and abnormal clinical exams increased the chances of making a diagnosis, while swollen lymph nodes and spleen reduced those chances.
- - Overall, the prognosis for patients was positive, with a 58% recovery rate and a low fatality rate, although older patients and those with skin symptoms faced a higher risk of death.