Publications by authors named "A L Erwin"
Nuclear exclusion and cytoplasmic accumulation of the RNA-binding protein TDP43 are characteristic of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Despite this, the origin and ultrastructure of cytosolic TDP43 deposits remain unknown. Accumulating evidence suggests that abnormal RNA homeostasis can drive pathological TDP43 mislocalization, enhancing RNA misprocessing due to loss of nuclear TDP43 and engendering a cycle that ends in cell death.
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- * Multimodal cardiac imaging techniques, like echocardiography and cardiac MRI, are crucial for diagnosing and assessing the heart issues in FD patients.
- * The review highlights existing gaps in understanding cardiac findings in FD and emphasizes the importance of advanced imaging methods for better evaluation and management of the disease.
The primary motor cortex does not uniquely or directly produce alpha motoneurone (α-MN) drive to muscles during voluntary movement. Rather, α-MN drive emerges from the synthesis and competition among excitatory and inhibitory inputs from multiple descending tracts, spinal interneurons, sensory inputs, and proprioceptive afferents. One such fundamental input is velocity-dependent stretch reflexes in lengthening muscles, which should be inhibited to enable voluntary movement.
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- Musculoskeletal (MSK) issues are commonly seen by primary care doctors, but many lack proper training in MSK procedures, particularly in diagnostic and therapeutic injections which can be challenging.
- A study involving 24 Internal Medicine and Family Medicine residents tested the effectiveness of hands-on practice with cadavers versus visual instruction for performing subacromial injections, assessing both technique and accuracy.
- Results showed that while the practice group had significantly more accurate injections within the correct anatomical space, both groups had similar technique ratings, and the intervention group reported higher self-confidence in their abilities.