To get through to survive: Exploring the symptom cluster management process during oncological treatment from the perspective of patients with lung cancer - A grounded theory study.

Purpose: To explore the symptom cluster management process from the perspective of patients with lung cancer within the oncological care context.

Methods: We used a constructivist grounded theory methodology to collect and analyze rich data from 15 patients with lung cancer via individual interviews and a two-dimensional symptom assessment scale.

Results: A situational theoretical model describes the symptom cluster management process through the main category 'To get through to survive', with the category 'Handling symptom clusters' together with six sub-categories concerning the patients' management strategies and the category 'Living with symptom clusters,' together with two sub-categories describing the outcome in their daily life.

Politically Contaminated Clothes, Chocolates, and Charities: Distancing From Neutral Products Liked by Out-Group or In-Group Partisans.

This research demonstrates that people distance themselves not just from out-group partisans or policies but also from completely neutral and apolitical consumer products that have been "contaminated" simply by being preferred by the political out-group. Using large representative samples of Swedish adults, we investigated how aesthetic judgments of clothes (Study 1), evaluations of chocolate bars (Study 2), and allocations to charitable organizations (Study 3) were influenced by a randomly assigned association between these products and the leader or supporters of the participant's least- or most-liked political party. Products liked by the least-liked party became less attractive in all studies; the results were mixed for products liked by the most-liked party.

Tau processing and tau-mediated inflammation differ in human and astrocytes.

Alzheimer's disease (AD) and progressive supra-nuclear palsy (PSP) are both proteinopathies, characterized by the accumulation of tau aggregates. is the greatest genetic risk factor for developing AD, while is a significant risk factor for developing PSP. In the brain, astrocytes are the predominant producer of ApoE, but they are also important for inflammation and overall brain homeostasis.

Mapping quality of life after balloon dilatation in subglottic stenosis using Dyspnea index and Short Form Health Survey-36.

Purpose: An accurate diagnosis and proper treatment plan are required to restore an adequate patent airway in fibrotic subglottic stenosis (SGS). Currently, the definitive treatment entails single-stage balloon dilatation with steroid injections. The primary aim was to evaluate successful airway restoration and general quality of life in cases with SGS in northern Sweden using robust patient reported outcomes.

Astrocytic accumulation of tau fibrils isolated from Alzheimer's disease brains induces inflammation, cell-to-cell propagation and neuronal impairment.

Accumulating evidence highlights the involvement of astrocytes in Alzheimer's disease (AD) progression. We have previously demonstrated that human iPSC-derived astrocytes ingest and modify synthetic tau fibrils in a way that enhances their seeding efficiency. However, synthetic tau fibrils differ significantly from in vivo formed fibrils.