Publications by authors named "A L De Lacey"
Article Synopsis
- Oxidoreductase enzymes, important in organic synthesis and pharmaceuticals, rely on NADH for reactions, creating a need for cost-effective NADH regeneration methods.
- This study introduces a new amino-functionalized viologen that, when combined with diaphorase, effectively generates bioactive NADH with high selectivity and efficiency.
- Testing revealed that this system significantly enhanced formate production compared to traditional methods, highlighting its potential for sustainable NADH regeneration at low energy requirements.
Depsides have garnered substantial interest due to the diverse biological activities exhibited by members of this class. Among these are the antibacterial aquastatins, glycosylated heteromeric depsides formed through the condensation of orsellinic acid with corticiolic acid. In this work, we isolated aquastatins and the recently described geministatins, along with several novel aquastatin-related depsides with different alkyl side chains from the fungus MST-FP2131.
View Article and Find Full Text PDFThere is a great deal of interest in the development of electrocatalysts for the oxygen evolution reaction (OER) that are stable and have high activity because this anodic half-reaction is the main bottleneck in water splitting and other key technologies. Cobalt and iron oxide and oxyhydroxide electrocatalysts constitute a cheaper alternative to the highly active and commonly used Ir- and Ru-based catalysts. Most of the described electrocatalysts require tedious synthetic and expensive preparation procedures.
View Article and Find Full Text PDFWomen live longer than men but spend more years in poor health. Menopausal symptoms are not generally associated with adverse health outcomes. However, increasingly, evidence suggests they can significantly impact future health and longevity.
View Article and Find Full Text PDFBackground And Objective: Information on self-limited epilepsy with centrotemporal spikes (SeLECTS) epidemiology is limited. We aimed to determine the incidence of SeLECTS in children, its association with socioeconomic deprivation and the prevalence of neurodevelopmental comorbidities.
Method: We performed a retrospective cohort study (2004-2017) using anonymised, linked, routinely collected, primary care and demographic data for children in Wales.