Transformation of Cannabidiol (CBD) during its high-temperature extraction: Studies involving model systems, hemp and functional foods containing CBD.

Most approaches to plants and foodstuffs analysis involve the application of liquid extraction methods for the isolation of their components. The present paper shows and discusses the transformations that CBD may undergo during its high-temperature extraction with methanol, dichloromethane, ethyl acetate and hexane from hemp and CBD containing commercially available functional foods. According to the performed research, CBD can transform not only into cannabinoids, which are hemp metabolites (i.

Xenobiotics recovery from plasma using solid phase extraction with C-18 sorbent - The reasons of literature discrepancies.

Solid phase extraction (SPE) is one of the most popular methods of preparing plasma samples before determining the xenobiotics they contain. The present paper shows that the recovery degree of xenobiotics from plasma samples using SPE with C18 sorbent strongly depends on their storage time and temperature. While xenobiotics can be isolated and recovered in 100 % from fresh plasma samples under optimal conditions of the SPE procedure, their SPE recovery degree from stored plasma is lower.

A Web-GIS tool for diagnosing spatial orientation of young adults: design and evaluation of Geo-Survey.

Spatial orientation is the effectiveness with which one is able to assess the mutual location of objects relative to a point of reference or a system of coordinates. Traditionally, this ability has been evaluated through field navigation tests, which do not take into account the prevailing influence of free online maps and virtual walks on a person's interpretation of space. In this context, this study presents a Web-GIS tool designed and developed to examine spatial orientation skills in the context of the used map type.

Cannabigerol (CBG) signal enhancement in its analysis by gas chromatography coupled with tandem mass spectrometry.

Purpose: According to recent reports, cannabigerol (CBG) concentration level in blood and body fluids may have forensic utility as a highly specific albeit insensitive biomarker of recent cannabis smoking. While the analytical sensitivity of cannabidiol (CBD), Δ-tetrahydrocannabinol (Δ-THC), cannabichromene (CBC) or cannabinol (CBN) estimation by gas chromatography-mass spectrometry (GC-MS) is similar and sufficiently high, it is exceptionally low in the case of CBG (ca. 25 times lower than for the other mentioned cannabinoids).

Synthesis and anthelmintic activity of novel thiosemicarbazide and 1,2,4-triazole derivatives: In vitro, in vivo, and in silico study.

Introduction: Intestinal parasitic infections are neglected diseases and, due to the increasing resistance of parasites to available drugs, they pose an increasing therapeutic challenge. Therefore, there is a great need for finding new compounds with antiparasitic activity.

Objectives: In this work, new thiosemicarbazide and 1,2,4-triazole derivatives were synthesized and tested for their anthelmintic activity.