Publications by authors named "A L Darling"
Article Synopsis
- A systematic review analyzed the relationship between vitamin D status and immune function in dark-skinned individuals, focusing on acute respiratory tract infections (ARTI).
- Researchers reviewed 2077 articles and included 18 studies in the analysis, but only three high-quality RCTs offered strong enough data for further assessment.
- The findings indicated a possible inverse link between vitamin D levels and inflammation or ARTI occurrence; however, vitamin D supplementation showed no significant effect on ARTI rates amongst ethnic minority groups, highlighting the need for more diverse research.
Article Synopsis
- The study focused on establishing continuous reference intervals for cerebrospinal fluid (CSF) biomarkers homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), which are important for diagnosing neurological diseases related to dopamine and serotonin.
- Utilizing data from a large cohort of pediatric patients, researchers created age-specific models to define these intervals more accurately, addressing the issue of not having healthy control groups.
- The results showed that the continuous reference intervals reduced the number of secondary deficiencies identified and found no significant links between HVA and 5-HIAA levels and the effects of antiepileptic or neuroleptic medications, indicating that these biomarkers may not always correlate with neurological disorders.
Objective: This study aimed to assess the rates of vaginal delivery (VD) and the predictors of VD in a cohort of patients with early (<34 weeks) preeclampsia with severe features (Early Severe PreEClampsia [ESPEC]).
Study Design: We conducted a retrospective cohort study of patients with ESPEC admitted to a single center from 2013 to 2019. Exclusion criteria included patients with contraindications to labor, multifetal gestation, or presenting in spontaneous labor.
Characterizing the timing of menarche and the factors that are associated with it is important for understanding a population's reproductive health needs and long-term health trajectories. We estimated the age at the menstrual onset among adolescent girls and the association between dietary and nutritional factors and menarche in four sub-Saharan African urban sites. We used cross-sectional school-based data from 2307 female adolescents aged 10-14 years collected by the Africa Research, Implementation Science, and Education (ARISE) Network in Ouagadougou, Burkina Faso; Addis Ababa, Ethiopia; Khartoum, Sudan; and Dar es Salaam, Tanzania.
View Article and Find Full Text PDFAim: This exploratory study evaluates rating scale usage by experts from the European Reference Network for Rare Neurological Diseases (ERN-RND) for paediatric MD, considering factors like diagnosis, intellectual disability, age, and transition to adult care. The aim is to propose a preliminary framework for consistent application.
Methods: A multicentre survey among 25 ERN-RND experts from 10 European countries examined rating scale usage in paediatric MD, categorizing MD into acute, non-progressive, and neurodegenerative types.