Publications by authors named "A L D'Rozario"
Background: Obstructive sleep apnea (OSA) is highly prevalent among older adults and has been associated with cognitive decline and dementia risk. The suitability of screening tools for detecting OSA in memory clinic settings is unclear.
Objective: To evaluate the utility and validity of the STOP-Bang questionnaire (SBQ) and pulse oximeter as a screening tool, compared to gold-standard polysomnography (PSG) in older adults attending a memory clinic.
During the COVID-19 pandemic, studies reported that restricted living conditions were associated with worse subjective sleep quality. This effect might have been caused by reduced light exposure during lockdowns. We investigated light exposure levels, subjective and objective sleep and physical activity levels in older adults during restricted and free-living conditions after the pandemic.
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- Sleep architecture in people with depression, especially older adults, is not well-defined, prompting a study to compare sleep patterns between depressed and non-depressed individuals aged over 50.
- A systematic review identified 15 articles from over 2000, with data showing that depressed adults had significantly poorer sleep quality — less total sleep time, longer time to fall asleep, and more disruptions during the night compared to controls.
- Although older depressed adults had some distinct sleep characteristics, inconsistencies in findings and the removal of certain studies affected the overall results, indicating that differences in sleep architecture vary among different age groups and are not consistently observed.
Background And Purpose: Obstructive sleep apnea is associated with increased dementia risk. Nocturnal hypoxemia, which can be more severe during rapid eye movement (REM) sleep, may be a key mechanism. This study examines how REM hypoxemia affects memory and explores whether hippocampal vulnerability to hypoxemia mediates this effect in older adults at risk for dementia.
View Article and Find Full Text PDFEvaluating possible 'next day' impairment in insomnia patients administered an oral medicinal cannabis product by night: a pilot randomized controlled trial.
Psychopharmacology (Berl)
September 2024
Cannabis and its major constituents, Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD), are being widely used to treat sleep disturbances. However, THC can cause acute cognitive and psychomotor impairment and there are concerns that driving and workplace safety might be compromised the day after evening use. Here, we examined possible 'next day' impairment following evening administration of a typical medicinal cannabis oil in adults with insomnia disorder, compared to matched placebo.
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