Biomarkers.

Background: Repetitive head impacts (RHI) from contact sports can lead to long-term white matter injury visualized on FLAIR scans as white matter hyperintensities (WMH). The goal of this study was to preliminarily characterize the unique pattern and features of WMH in middle aged- to older adults with remote history of exposure to RHI from contact sports.

Method: 76 participants (38 with substantial RHI, 38 with minimal or no RHI) from the Boston University Alzheimer's Disease Research Center had a FLAIR MRI during their annual study visit.

Viral oncogene EBNALP regulates YY1 DNA binding and alters host 3D genome organization.

The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNALP) is essential for the immortalization of naive B lymphocytes (NBLs). However, the mechanisms remain elusive. To understand EBNALP's role in B-cell transformation, we compare NBLs infected with wild-type EBV and an EBNALP-null mutant EBV using multi-omics techniques.

Sodium dodecyl sulfate-coated silver nanoparticles accelerate antimicrobial potentials by targeting amphiphilic membranes.

Compelling concerns about antimicrobial resistance and the emergence of multidrug-resistant pathogens call for novel strategies to address these challenges. Nanoparticles show promising antimicrobial activities; however, their actions are hindered primarily by the bacterial hydrophilic-hydrophobic barrier. To overcome this, we developed a method of electrochemically anchoring sodium dodecyl sulfate (SDS) coatings onto silver nanoparticles (AgNPs), resulting in improved antimicrobial potency.

A nonlinear creep model of hard structural planes.

Hard structural planes mainly exist in rock slopes and their creep characteristics largely determine slope stability. Traditional models have some shortcomings in describing the creep characteristics of hard structural planes, such as poor adaptability and unclear physical meaning of parameters. In order to overcome these shortcomings, based on the creep failure mechanism of hard structural planes, an element combination model is adopted in the study.