Publications by authors named "A L Crago"
Background: Antimicrobial use (AMU) is a known driver of antimicrobial resistance. Insight into prevalence and correlates of AMU can help identify health inequities and areas for targeted action. To better understand sociodemographic and medical dimensions of AMU in Canada, the Public Health Agency of Canada, in partnership with Statistics Canada, developed a Rapid Response Module questionnaire on self-reported oral antibiotic use, to be administered as part of the 2018 Canadian Community Health Survey (CCHS).
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- Improved prognostic tools are essential for patients with locally recurrent soft tissue sarcoma (STS), prompting an investigation into how the average local recurrence growth rate influences patient outcomes after resection.
- The study analyzed data from 253 patients, revealing a 5-year cumulative incidence of disease-specific death (DSD) at 29%, with several factors like LR growth rate, age, and tumor characteristics significantly impacting outcomes.
- Key findings outlined that faster local recurrence growth and other specific tumor traits were associated with a higher risk of DSD, highlighting the need for precise tools to assess patient prognosis effectively.
Article Synopsis
- Desmoid tumors (DT) are rare, aggressive growths that have historically been treated primarily with surgery, but recent trends suggest a shift towards less invasive treatment options.
- A consensus meeting held in Milan in June 2023 aimed to update global guidelines for DT management, bringing together over 90 experts and patient advocates to discuss new strategies and treatments.
- The updated guidelines emphasize the importance of local therapies and include information on the latest medical agents, particularly γ-secretase inhibitors, to ensure informed and effective management of DT in specialized referral centers.
Both primary and secondary breast angiosarcoma (AS) are characterized by multifocal presentation and aggressive behavior. Despite multimodality therapy, local and distant relapse rates remain high. Therefore, neoadjuvant chemotherapy (NACT) is employed to improve the R0 resection rates and survival, but its benefits remain controversial.
View Article and Find Full Text PDFPurpose: This study sought to identify β-catenin targets that regulate desmoid oncogenesis and determine whether external signaling pathways, particularly those inhibited by sorafenib (e.g., PDGFRβ), affect these targets to alter natural history or treatment response in patients.
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