Publications by authors named "A L Coughtrie"
Respiratory tract infections are responsible for over 2.8 million deaths per year worldwide. Colonization is the first step in the process of microbes occupying the respiratory tract, which may lead to subsequent infection.
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- Respiratory tract infections (RTIs) cause over 2.8 million deaths annually, and understanding the carriage of bacterial and viral pathogens is essential for infection prevention.
- Samples were collected from individuals at two points in time to analyze the presence of various respiratory pathogens using culture and PCR methods.
- Carriage patterns showed significant variations based on age, recent RTI history, and species interactions, revealing complex ecological dynamics that influence microbial community assembly in the respiratory tract.
Objectives: To establish a unique sample of proarrhythmia cases, determine the characteristics of cases and estimate the contribution of individual drugs to the incidence of proarrhythmia within these cases.
Setting: Suspected proarrhythmia cases were referred by cardiologists across England between 2003 and 2011. Information on demography, symptoms, prior medical and drug histories and data from hospital notes were collected.
Introduction: Clinical trials have identified peripheral oedema (PO) as an adverse event of vildagliptin (an oral anti-diabetic drug [OAD]). A post-marketing study (PMS) was conducted to advance the understanding of vildagliptin use and particular safety concerns identified within the risk-management plan. PMS objectives included comparing the hazards between vildagliptin monotherapy and combination therapy for selected a priori identified risks, including PO.
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