Publications by authors named "A L Coakley"
Objectives: The aims of this study were to 1) categorize and quantify the most frequent concerns of informal caregivers, 2) conduct a thematic analysis on a sample of the posts, and 3) examine a subset of 100 post responses to determine if they are supportive and evidence- based.
Method: For Aims 1 and 2, we used a qualitative descriptive design using content analysis. To address Aim 3, we used a Delphi method in a subset sample of responses to posts to determine if they were supportive or not and evidence-based or not.
Article Synopsis
- - Mechanical stress refers to how materials resist internal forces like compression or tension, with significant implications for aging and health, as changes in the extracellular matrix can affect tissue stiffness.
- - Aging tissues such as ovaries, skin, and blood vessels become stiffer, which can lead to decreased organ function, prompting research into how mechanical stress influences cell and tissue health.
- - A study using C. elegans showed that altering the stiffness of the agar medium had limited effects on various health aspects, highlighting the need for researchers to consider agar choices in their experiments.
The capacity to deal with stress declines during the aging process, and preservation of cellular stress responses is critical to healthy aging. The unfolded protein response of the endoplasmic reticulum (UPR) is one such conserved mechanism, which is critical for the maintenance of several major functions of the ER during stress, including protein folding and lipid metabolism. Hyperactivation of the UPR by overexpression of the major transcription factor, , solely in neurons drives lifespan extension as neurons send a neurotransmitter-based signal to other tissue to activate UPR in a non-autonomous fashion.
View Article and Find Full Text PDFHumans are living longer, but this is accompanied by an increased incidence of age-related chronic diseases. Many of these diseases are influenced by age-associated metabolic dysregulation, but how metabolism changes in multiple organs during aging in males and females is not known. Answering this could reveal new mechanisms of aging and age-targeted therapeutics.
View Article and Find Full Text PDFObjective: This study aimed to evaluate if and how race, ethnicity, and socioeconomic status (SES) are associated with the severity of menopause symptoms in a large, diverse sample of women.
Methods: For this cross-sectional study conducted between March 24, 2019, and January 13, 2023, a total of 68,864 women were enrolled from the Evernow online telehealth platform. Participants underwent a clinical intake survey, which encompassed demographic information, detailed medical questionnaires, and a modified Menopause Rating Scale.