Publications by authors named "A L Childress"
Substance use disorders (SUDs) are a significant public health concern, with over 30% failing available treatment. Severe SUD is characterized by drug-cue reactivity that predicts treatment-failure. We leveraged this pathophysiological feature to personalize deep brain stimulation (DBS) of the nucleus accumbens region (NAc) in an SUD patient.
View Article and Find Full Text PDFThe ability to adapt to changing circumstances has strong survival value. Individuals with substance use disorders tend to get "stuck" over-responding to drug-reward signals and pursuing drugs despite negative consequences. A lack of flexibility may be tied to impairments in neurocognition, including learning, memory, and executive function.
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- Most people in the US are exposed to PFAS, which can lead to health risks, especially in low-income communities near PFAS-polluting facilities.
- In a study in Southern California, researchers connected PFAS levels in plasma samples with data on water contamination, food access, and pollution sources to analyze exposure impacts.
- Results showed that higher PFAS levels in drinking water and the presence of Superfund sites increased PFAS concentrations in participants' blood, highlighting the need to address PFAS exposure in disadvantaged areas.