Publications by authors named "A L Carl"
Waldenstrom macroglobulinemia (WM) is a non-Hodgkin B-cell lymphoma, characterized by bone marrow infiltration with plasma cells and lymphocytes. The tumor microenvironment (TME) plays an important role in mediating WM cell biology, but the effects of macrophages on WM biology remains unclear. Here, we investigated the effects of macrophages on WM growth and survival and identified a novel role for transcription factor GLI3 in macrophage polarization.
View Article and Find Full Text PDFArticle Synopsis
- The article DOI: 10.1016/j.dadr.2023.100138 contains a correction to previously published research.
- This correction may involve updates to data, conclusions, or authorship that are significant for academic accuracy.
- Readers should refer to the corrected version for the most accurate information regarding the study.
Article Synopsis
- * A survey conducted among participants from two SCA registries received responses from 303 individuals and caregivers, covering a wide age range and various SCA types.
- * The survey results highlighted the SCA community's main priorities for health, emphasizing the need for intervention studies and clinical treatments, indicating a strong desire for targeted research in this area.
Cells mechanically interface with their surroundings through cytoskeleton-linked adhesions, allowing them to sense physical cues that instruct development and drive diseases such as cancer. Contractile forces generated by myosin motor proteins mediate these mechanical signal transduction processes through unclear protein structural mechanisms. Here, we show that myosin forces elicit structural changes in actin filaments (F-actin) that modulate binding by the mechanosensitive adhesion protein α-catenin.
View Article and Find Full Text PDFArticle Synopsis
- Turner syndrome (TS) involves the absence of a sex chromosome, and this study focuses on a specific mosaic form (45,X/47,XXX) that is observed in about 3% of TS cases.
- The research compared health outcomes and medical conditions among females with 45,X/47,XXX against those with nonmosaic 45,X and mosaic 45,X/46,XX, finding that 45,X/47,XXX had fewer neonatal issues and lower rates of some TS diagnoses.
- However, they were more prone to structural kidney problems and congenital heart disease while also having less chance of spontaneous menarche, indicating distinct health profiles associated with their chromosomal patterns.