Publications by authors named "A L Caforio"
. Pericarditis has a heterogeneous clinical spectrum and rate of relapse. Data on aetiology, real-life treatment strategies, and long-term course from contemporary pericarditis cohorts are lacking.
View Article and Find Full Text PDFPrevalence and Correlates of Anti-DSG2 Antibodies in Arrhythmogenic Right Ventricular Cardiomyopathy and Myocarditis: Immunological Insights from a Multicenter Study.
J Clin Med
November 2024
Article Synopsis
- Autoantibodies against Desmoglein-2 (anti-DSG2-ab) were found in patients with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) and myocarditis, indicating a potential link to immune responses against desmosomal proteins.
- The study aimed to evaluate the specificity of anti-DSG2-ab in ARVC, compare detection methods (ELISA vs. IFL), and identify clinical correlates related to these antibodies among various patient groups.
- In a cohort of patients, 56% of those with ARVC tested positive for anti-DSG2-ab, showing a higher rate of positivity in those also positive for anti-intercalated disk autoantibodies (A
The role of the immune system in myocarditis onset and progression involves a range of complex cellular and molecular pathways. Both innate and adaptive immunity contribute to myocarditis pathogenesis, regardless of its infectious or non-infectious nature and across different histological and clinical subtypes. The heterogeneity of myocarditis etiologies and molecular effectors is one of the determinants of its clinical variability, manifesting as a spectrum of disease phenotype and progression.
View Article and Find Full Text PDFAims: Standardized immunosuppressive therapy (IS) had been previously investigated in biopsy-proven (BP) lymphocytic myocarditis with heart failure (HF). This study evaluated efficacy and safety of tailored IS in BP immune-mediated myocarditis, irrespective of histology and clinical presentation.
Methods And Results: Consecutive BP myocarditis patients treated with long-term tailored IS on top of optimal medical therapy (OMT), were compared with OMT non-IS controls using propensity-score weighting.