Publications by authors named "A L Bokde"
Article Synopsis
- The study utilized machine learning models to identify reliable diagnostic markers for eating disorders, major depressive disorder, and alcohol use disorder, targeting young adults aged 18-25.
- The classification models showed high accuracy rates (AUC-ROC ranging from 0.80 to 0.92) even without considering body mass index and highlighted shared predictors like neuroticism and hopelessness.
- Additionally, the models were moderately successful in predicting future symptoms related to eating disorders, depression, and alcohol use in a longitudinal sample of adolescents, indicating the potential for improved diagnosis and risk assessment in mental health.
Introduction: A growing literature has shown that exposure to adverse life events during childhood or adolescence is associated with the presence of psychotic-like experiences (PLEs), which is in turn associated with the risk of psychotic outcomes. Ruminative thinking, i.e.
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- This study uses multi-modal MRI to investigate neurobiological differences between anorexia nervosa (AN) and bulimia nervosa (BN), revealing structural and functional brain changes linked to these eating disorders.
- Key findings include reduced gray matter volume in specific brain regions (like the orbitofrontal cortex) and decreased cortical thickness, particularly in anorexia patients, which are associated with impulsivity and cognitive restraint regarding eating behaviors.
- The results suggest that these brain changes affect reward processing and contribute to the persistence of eating disorder symptoms, highlighting potential targets for future treatment interventions.
Article Synopsis
- * A study utilizing the Adolescent Brain Cognitive Development cohort revealed seven genomic regions where gene-environment interactions affect gray matter volume, tied to metabolic and inflammatory processes, as well as synaptic plasticity.
- * The analysis highlighted that socioeconomic status, rather than family environment, plays a crucial role in how maternal education influences genetic effects on neurodevelopment, offering insights into the biological and social mechanisms involved.
Aim: Immune dysregulation and delayed onset of sleep wake cycling (SWC) are associated with worse outcome in neonatal encephalopathy (NE), however the association between sleep and immune dysfunction in NE remains unclear. Aimed to evaluate association of sleep and systemic inflammation with outcomes in NE.
Methods: Amplitude-integrated electroencephalography (aEEG) recordings were collected on infants undergoing therapeutic hypothermia (TH).