Publications by authors named "A L Belchior"
Currently, COVID-19 and tuberculosis (TB) are the deadliest infectious diseases worldwide. Their synergy, form of presentation, morbidity, and mortality are data that have been scarcely explored. Thus, this study aimed to characterize the clinical, epidemiological, and laboratory factors of this co-infection and to analyze the factors associated with the active TB among COVID-19 cases.
View Article and Find Full Text PDFArticle Synopsis
- The study details the creation of an iodine-labeled acridine orange compound ([I]-C) designed to bind G-quadruplexes, with a focus on its potential use in Auger Electron Radiopharmaceutical Therapy (AE-RPT) for treating cervical cancer.
- [I]-C showed significant cellular uptake in HeLa cervical cancer cells, leading to reduced cell viability and severe DNA damage likely caused by the emitted Auger Electrons from iodine.
- Although [I]-C exhibited fast clearance from the bloodstream and good stability, it had poor tumor uptake; combining it with the AS1411 aptamer improved blood retention but did not enhance tumor targeting, suggesting that new delivery methods need to
The main goal of this work was to elucidate the potential relevance of (radio)metal chelates of Tc and Re targeting G-quadruplex structures for the design of new tools for cancer theranostics. Tc provides the complexes with the ability to perform single-photon-emission computed tomography imaging studies, while the Re complexes should act as anticancer agents upon interaction with specific G4 DNA or RNA structures present in tumor tissues. Towards this goal, we have developed isostructural Tc(I) and Re(I) tricarbonyl complexes anchored by a pyrazolyl-diamine (Pz) chelator carrying a pendant pyridostatin (PDS) fragment as the G4-binding motif.
View Article and Find Full Text PDFObjectives: to map, in the world literature, instruments for assessing foot self-care of people with diabetes.
Methods: a scoping review in Scopus by Elsevier, MEDLINE via PubMed, LILACS, SciELO databases and gray literature, using the controlled words diabetic foot, self care, questionnaire. Search was carried out in February and March 2021, according to JBI recommendations and PRISMA-ScR extension.