Publications by authors named "A L Basquiera"
Article Synopsis
- Common variable immunodeficiency (CVID) is a prevalent immunodeficiency condition, with only about 30% of cases having a defined genetic cause, highlighting a gap in understanding mortality risk factors.
- Researchers conducted a study on 21 patients in Córdoba, Argentina, examining their clinical data and immune cell types to develop a mortality predictive score.
- Key findings revealed that lower counts of CD4 T cells, natural killer (NK) cells, and memory switched B cells were significantly associated with reduced survival rates, leading to the proposal of a scoring system based on these immune cell types to estimate mortality risk in CVID patients.
Background: The Molecular International Prognostic Scoring System (IPSS-M) has improved the prediction of clinical outcomes for myelodysplastic syndromes (MDS). The Artificial Intelligence Prognostic Scoring System for MDS (AIPSS-MDS), based on classical clinical parameters, has outperformed the IPSS, revised version (IPSS-R). For the first time, we validated the IPSS-M and other molecular prognostic models and compared them with the established IPSS-R and AIPSS-MDS models using data from South American patients.
View Article and Find Full Text PDFIntroduction: The treatment of elderly multiple myeloma (MM) patients with autologous stem cell transplantation (ASCT) is a controversial procedure. Most clinical trials evaluating the safety and efficacy of ASCT have primarily included patients younger than 65 years.
Design And Methods: This was a retrospective analysis of patients with MM who underwent ASCT between 2008 and 2018.
Wiskott-Aldrich syndrome (WAS) is an X-linked genetic disorder caused by mutations in the gene that encodes the Wiskott-Aldrich syndrome protein (WASp). Here, we report the clinical case of an 18-month-old boy diagnosed with Wiskott-Aldrich syndrome, who did not have an HLA-matched related or unrelated donor and was treated successfully with a hematopoietic stem cell transplant (HSCT) from a haploidentical family donor. Graft-versus-host disease (GvHD) prophylaxis included post-transplant cyclophosphamide (PT-Cy).
View Article and Find Full Text PDFArticle Synopsis
- Hodgkin lymphoma (HL) is a type of cancer that originates from B lymphocytes and can occasionally lead to neurological issues, either through direct invasion or as paraneoplastic syndromes.
- The most common neurological syndrome linked to HL is paraneoplastic cerebellar degeneration, but others like limbic encephalitis and neuronopathy can also occur.
- A case study highlighted a woman whose HL first showed symptoms of sensory and autonomic neuronopathy, where treatment for HL led to significant improvement in autonomic symptoms, though sensory symptoms showed only limited recovery.