Publications by authors named "A L Alexandrov"
Background: Microembolic signals (MES) can be detected using transcranial Doppler (TCD) ultrasound in several clinical scenarios, including acute ischemic stroke (AIS). This narrative review aims to provide insights into their role in AIS patient management and outcomes.
Methods: The present narrative review consolidates current observational and randomized evidence on the prevalence and clinical relevance of MES in different AIS subtypes and settings.
Article Synopsis
- This study assesses the cost-effectiveness of mobile stroke units (MSUs) compared to standard emergency medical services (EMS) for administering thrombolytics in ischemic stroke patients.
- The analysis used the incremental cost-effectiveness ratio (ICER) method to evaluate healthcare costs and quality-adjusted life years (QALYs), highlighting considerable variations based on patient disability status and treatment costs.
- Overall, while MSUs show borderline cost-effectiveness for all eligible patients, they are more favorable for patients without pre-existing disabilities, particularly when focusing on lifetime costs and stroke-specific expenses.
Mechanical asphyxia is a severe condition caused by a physical blockage that impedes breathing in the upper airways, trachea, and lungs. We present a case of a 39-year-old man who died suddenly at home while getting ready for work. He had previously experienced shortness of breath and a sore throat.
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- Yeast cells maintain low cytosolic calcium levels using transporters, with the vacuolar Ca ATPase Pmc1 playing a key role in this process.
- Inactivation of Pmc1 leads to hypersensitivity to sodium dodecyl sulfate (SDS), which can be counteracted by inactivating the high-affinity calcium channel Cch1.
- Low concentrations of SDS cause a quick influx of external calcium into the cells, but the mechanism of Cch1's involvement suggests it has additional functions unrelated to its role in calcium transport.
Article Synopsis
- Alzheimer's disease is associated with impaired proteostasis, and enhancing it might help delay cognitive decline.
- KPT-330 (Selinexor), an XPO1 inhibitor, shows promise in improving proteostasis and enhancing autophagy in neurons, leading to better memory in Alzheimer's models.
- While KPT-330 increased overall amyloid deposition in the brain, it also resulted in lower levels of amyloid in specific areas like the thalamus, indicating that its effects on proteostasis and amyloid formation are region-specific.