Partial response of angiosarcoma of the scalp to sorafenib: association with decreased expression of vascular endothelial growth factors and their receptors.

The prognosis of angiosarcoma remains very poor, even with combined, multimodal therapy. We report a case with partial response of angiosarcoma of the scalp to sorafenib, which is a new oral, molecular, targeted, multiple-kinase inhibitor. In addition, we confirmed, using immunohistochemistry, that sorafenib suppressed the expression of vascular endothelial growth factors and their receptors on the angiosarcoma tumour cells, and decreased cell numbers by inhibiting cellular proliferation.

[Investigation of mites in the houses of atopic dermatitis (AD) patients, and clinical improvements by mite elimination].

Seasonal variations related to mites were investigated by the Methylene Blue Agar (MBA) method in the houses of 157 AD patients living in Tokyo. Many mites were counted in the dust from carpets, Japanese straw mats (Tatami) and the floor under Tatami. In most places, the number of mites was found to increase in summer.

[Result of "as is patch test" using mite elements in atopic dermatitis (AD) patient. 2nd report, "Mite lipid"].

The antigenicity of mite lipid was studied, taking atopic dermatitis as an allergic disease. Lipid was extracted from Dermatophagoides pteronyssinus (Dp) and D. farinae (Df).