Publications by authors named "A Kumar Arun"
Hutchinson-Gilford Progeria syndrome (HGPS) serves as a prominent model for Progeroid syndromes, a group of rare genetic disorders characterized by accelerated aging. This review explores the genetic basis, clinical presentation, and complications of HGPS. HGPS is caused by mutations in the LMNA gene, resulting in the production of a defective structural protein, prelamin A.
View Article and Find Full Text PDFBacterial cells secrete extracellular vesicles (EVs), the function of which is a matter of intense investigation. Here, we show that the EVs secreted by the human pathogen (pneumococcus) are associated with bacterial DNA on their surface and can deliver this DNA to the transformation machinery of competent cells. These findings suggest that EVs contribute to gene transfer in Gram-positive bacteria and, in doing so, may promote the spread of drug resistance genes in the population.
View Article and Find Full Text PDFKetone body oxidation and susceptibility to ethyl acetoacetate in a novel hemolytic multidrug-resistant strain Leptospira interrogans KeTo originated from sewage water.
Sci Rep
October 2024
Article Synopsis
- Terrestrial and aquatic environments contaminated with animal urine can spread Leptospira, which causes leptospirosis in both humans and animals, but the factors influencing its growth and virulence are not fully understood.
- A new strain of Leptospira interrogans, named KeTo, was isolated from sewage in India and can oxidize various organic acids, demonstrating susceptibility to ethyl acetoacetate that inhibits its growth and biofilm formation.
- Genetic analysis revealed that KeTo shares a high similarity to pathogenic strains and has specific genes for utilizing acetoacetate, indicating its metabolic capabilities and the need for further research on its growth inhibition.
Here, we report a draft metagenome-assembled genome and annotation of sp. obtained from the sequenced genome of . The genome completeness was 97.
View Article and Find Full Text PDFBackground: Stroke is a leading cause of death and disability worldwide. In India, it is the fourth leading cause of death and fifth leading cause of disability, posing a major public health concern. National surveys reveal an increasing trend in stroke risk factors such as tobacco use, physical activity, alcohol use, hypertension, and dyslipidemia.
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