Publications by authors named "A Kukuljac"
PURPOSE OF THE STUDY The hip fracture is the leading cause of disability and deaths in elderly. If left untreated, the hip fracture results in inability to walk, and therefore the patient is dependent on the other's people help. The aim of this study was to determine the predictive values of the functional status, present comorbidities, and the types of treatment on the long-term functional status and mortality in patients with the hip fracture.
View Article and Find Full Text PDFThe main protease (M) of SARS-CoV-2 is a validated antiviral drug target. Several M inhibitors have been reported with potent enzymatic inhibition and cellular antiviral activity, including , , , and , with each containing a reactive warhead that covalently modifies the catalytic Cys145. Coupling structure-based drug design with the one-pot Ugi four-component reaction, we discovered one of the most potent noncovalent inhibitors, () that is structurally distinct from the canonical M inhibitor .
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate how therapeutic hypothermia impacts the outcomes of patients who suffered out-of-hospital cardiac arrest (OHCA) after they regained spontaneous circulation.
- The results indicated that factors like multiple organ dysfunction syndrome (MODS), the initial heart rhythm (ventricular fibrillation), and the level of coma (measured by the Glasgow Coma Scale) significantly affected patient survival rates.
- Therapeutic hypothermia showed promise as a treatment option, particularly since ventricular fibrillation was identified as a positive predictor for recovery in these patients.
Objective: The aim of the study was to describe the prevalence of hyperlactatemia and emphasis on repeated lactate measurements in critically ill patients, and the associated mortality.
Materials And Methods: The study included 70 patients admitted in the Medical Intensive Care Unit at the Clinical Center, University of Sarajevo, in a 6-month period (July - December 2015). The following data were obtained: age, gender, reason for admission, Simplified Acute Physiology Score II, Acute Physiology and Chronic Health Evaluation, lactate concentrations upon admission, after 24 and 48 hours, and outcome (discharge from hospital or death).
Objective: We present the use of targeted temperature management in a tertiary-level intensive care unit, in three patients who experienced an out-of-hospital cardiac arrest.
Case Report: Three young patients experienced an out-of-hospital non-coronary cardiac arrest. The causes of the cardiac arrest were: Wolf-Parkinson-White syndrome, drug overdose and long-QT syndrome.