Age-related changes in mobility assessments correlate with repetitive goal-directed arm-movement performance.

Background: There is ample evidence that mobility abilities between healthy young and elderly people differ. However, we do not know whether these differences are based on different lower leg motor capacity or instead reveal a general motor condition that could be detected by monitoring upper-limb motor behavior. We therefore captured body movements during a standard mobility task, namely the Timed Up and Go test (TUG) with subjects following different instructions while performing a rapid, repetitive goal-directed arm-movement test (arm-movement test).

Motion Biomarkers Showing Maximum Contrast Between Healthy Subjects and Parkinson's Disease Patients Treated With Deep Brain Stimulation of the Subthalamic Nucleus. A Pilot Study.

Classic motion abnormalities in Parkinson's disease (PD), such as tremor, bradykinesia, or rigidity, are well-covered by standard clinical assessments such as the Unified Parkinson's Disease Rating Scale (UPDRS). However, PD includes motor abnormalities beyond the symptoms and signs as measured by UPDRS, such as the lack of anticipatory adjustments or compromised movement smoothness, which are difficult to assess clinically. Moreover, PD may entail motor abnormalities not yet known.

Correlations between Motor Symptoms across Different Motor Tasks, Quantified Random Forest Feature Classification in Parkinson's Disease.

Background: Objective assessments of Parkinson's disease (PD) patients' motor state using motion capture techniques are still rarely used in clinical practice, even though they may improve clinical management. One major obstacle relates to the large dimensionality of motor abnormalities in PD. We aimed to extract global motor performance measures covering different everyday motor tasks, as a function of a clinical intervention, i.

Bis-macrocyclic Ligands with Two Ferrocenyl End Groups, and Their Tetranuclear Dicopper(I) Compounds.

A series of bismacrocyclic ligands with two ferrocenyl groups, exo/endo-1,1':1' ',1' "-[1,2,4,5-tetrakis(5-aza-2-thiahexa-5-enyl)benzene]bisferrocene (exo/endo-FeBeFe), 1,1':1' ',1' "-[1,2:1',2'-tetrakis(5-aza-2-thiahexa-5-enyl)ethene]bisferrocene (1,2-FeEnFe), 1,1':1' ',1' "-[1,1':2,2'-tetrakis(5-aza-2-thiahexa-5-enyl)ethene]bisferrocene (1,1-FeEnFe), 1,1':1' ',1' "-[tetrakis(5-aza-2-thiahexa-5-enyl)methane]bisferrocene (FeMeFe), and their dicopper(I) compounds have been synthesized and characterized (electrochemistry, IR, NMR and Mössbauer spectroscopy). The molecular structure of endo-FeBeFe has been determined by X-ray structure analysis and the copper(I)-induced discrimination of the exo- and endo-isomers of FeBeFe has been investigated by (1)H NMR spectroscopy. The interaction between copper and iron in the tetranuclear compounds is discussed on the basis of the electrochemical and spectroscopic data.

Helical Figure-of-Eight Loop Dicopper(I) Compounds: Syntheses, Structures, and Dynamics.

The synthesis of a series of nine large macrocyclic ligands with two N(2)S(2) (thioether and Schiff-base imine) binding sites each, with different bridges between the donor atoms of each site (ethylene, o-xylylene, propylene, butylene) and different spacer groups between the two binding sites (p-xylylene, 2,5-dimethyl-p-xylylene, 2,5-dimethoxy-p-xylylene), and the synthesis of a similar ligand with a preorganized double-helical geometry, based on a paracyclophane spacer group, are reported, together with the syntheses and characterizations of the corresponding dicopper(I) compounds. The solid state structures of the dicopper(I) complexes have two tetrahedral copper(I) sites, separated by ca. 8 Å, and a figure-of-eight loop configuration of the ligand with a parallel arrangement of the two substituted benzene spacer groups (benzene.