Publications by authors named "A Kugadas"
Article Synopsis
- Fabry disease (FD) is a genetic disorder caused by mutations in the GLA gene, leading to the accumulation of harmful substances in cells and resulting in various health issues, including pain and severe complications in organs like the heart and kidneys.
- Current treatments can help preserve kidney function but are less effective for heart problems, highlighting the need for better research models to test new drug therapies.
- Two mouse models (GlaKO and G3Stg/GlaKO) have been developed to study FD, with the latter demonstrating more severe tissue and cardiac issues, and research aims to evaluate cardiac health using advanced imaging techniques.
The bactericidal function of neutrophils is dependent on a myriad of intrinsic and extrinsic stimuli. Using systems immunology approaches we identify microbiome- and infection-induced changes in neutrophils. We focus on investigating the Prenylcysteine oxidase 1 like (Pcyox1l) protein function.
View Article and Find Full Text PDFThe ocular surface was once considered immune privileged and abiotic, but recently it appears that there is a small, but persistent commensal presence. Identification and monitoring of bacterial species at the ocular mucosa have been challenging due to their low abundance and limited availability of appropriate methodology for commensal growth and identification. There are two standard approaches: culture based or DNA sequencing methods.
View Article and Find Full Text PDFWhy ocular mucosa is paucibacterial is unknown. Many different mechanisms have been suggested but the comprehensive experimental studies are sparse. We found that a deficiency in L-plastin (LCP1), an actin bundling protein, resulted in an ocular commensal overgrowth, characterized with increased presence of conjunctival spp.
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