Publications by authors named "A Krunic"
Article Synopsis
- - MicroRNAs, which are short non-coding RNAs, play a key role in protein regulation and are being explored as potential biomarkers for Alzheimer's disease (AD).
- - The study analyzed plasma samples from 847 participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) and discovered specific microRNA signatures that correlate with AD diagnosis and the progression from mild cognitive impairment (MCI) to AD.
- - Findings suggest that evaluating plasma microRNA levels, alongside neuropsychological tests, can enhance the prediction accuracy for MCI to AD conversion, potentially helping to identify at-risk individuals and reduce the need for costly diagnostic procedures.
Introduction: MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer's disease (AD) pathogenesis.
Methods: We investigated the association between baseline plasma miRNAs and central AD biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 803): amyloid, tau, and neurodegeneration (A/T/N). Differentially expressed miRNAs and their targets were identified, followed by pathway enrichment analysis.