Publications by authors named "A Krug"
Background: Peyronie's disease (PD) is a progressive fibrotic disorder of the penis that can induce pain and erectile dysfunction and has various treatment modalities, including surgical, pharmaceutical, and injection therapies.
Methods: The authors used electronic medical records from Kaiser Permanente Southern California, an integrated health care system that consists of 15 medical centers, and identified patients diagnosed with stable PD without concomitant erectile dysfunction from January 1, 2004, to December 31, 2020. Baseline characteristics between surgical and injection groups were compared using Chi-squared and Kruskal-Wallis tests.
Article Synopsis
- Plasmacytoid dendritic cells (pDCs) are important for immune responses but are rare in blood and less effective in cancer, making their use in therapies difficult.
- Researchers developed a new method to differentiate pDCs from cord blood stem cells using specific growth factors like SR-1 and GM-CSF, leading to a significant yield of functional pDCs.
- The study found that these cord blood-derived pDCs closely resemble primary pDCs and can potentially enhance anti-tumor immune responses, making them promising candidates for cancer therapies.
Disorders across the affective disorders-psychosis spectrum such as major depressive disorder (MDD), bipolar disorder (BD), schizoaffective disorder (SCA), and schizophrenia (SCZ), have overlapping symptomatology and high comorbidity rates with other mental disorders. So far, however, it is largely unclear why some of the patients develop comorbidities. In particular, the specific genetic architecture of comorbidity and its relationship with brain structure remain poorly understood.
View Article and Find Full Text PDFIntroduction: Patient medical and surgical history factors, such as prior prostatectomy, may lead surgeons to opt for ectopic reservoir placement rather than the standard reservoir location in the retropubic space (RPS) during inflatable penile prosthesis (IPP) placement.
Objective: To examine the safety and effectiveness of ectopic reservoir placement used with three-piece IPPs in relation to reservoir placement in the RPS.
Methods: A systematic review of MEDLINE/Pubmed and Embase databases was performed for literature between 1970 and 2022.