Publications by authors named "A Krishnaraj"
Article Synopsis
- A fetus at 30 weeks gestation with severe complications due to a large vein of Galen malformation (VOGM) was treated with glue embolization after being referred for pregnancy termination.
- The procedure successfully corrected blood flow issues and showed improvements in heart size and fetal brain structure, leading to a stable delivery.
- Despite initial success, the newborn faced severe health challenges and ultimately passed away, highlighting the complexities and risks involved in prenatal interventions for VOGM.
Article Synopsis
- Cisplatin and carboplatin are widely used platinum-based chemotherapy drugs, treating around half of cancer patients, but face challenges like resistance and severe side effects.
- * Cisplatin binds to DNA and can be less effective in some patients due to reduced uptake, highlighting the need for better monitoring of drug concentrations in cells.
- * The article details a protocol using ICP-MS to quantify cisplatin levels in cancer cells, applicable to various cell types, aimed at improving treatment efficacy with minimal toxicity.
Background MRI plays a crucial role in restaging locally advanced rectal cancer treated with total neoadjuvant therapy (TNT); however, prospective studies have not evaluated its ability to accurately select patients for nonoperative management. Purpose To evaluate the ability of restaging MRI to predict oncologic outcomes and identify imaging features associated with residual disease (RD) after TNT. Materials and Methods This was a secondary analysis of the Organ Preservation in Rectal Adenocarcinoma (OPRA) trial, which randomized participants from April 2014 to March 2020 with stages II or III rectal adenocarcinoma to undergo either induction or consolidation TNT.
View Article and Find Full Text PDFGLP-1RA therapy increases circulating vascular regenerative cell content in people living with type 2 diabetes.
Am J Physiol Heart Circ Physiol
August 2024
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 (SGLT2) inhibitors are guideline-recommended therapies for the management of type 2 diabetes (T2D), atherosclerotic cardiovascular disease, heart failure, and chronic kidney disease. We previously observed in people living with T2D and coronary artery disease that circulating vascular regenerative (VR) progenitor cell content increased following 6-mo use of the SGLT2 inhibitor empagliflozin. In this post hoc subanalysis of the ORIGINS-RCE CardioLink-13 study (ClinicalTrials.
View Article and Find Full Text PDFVascular regenerative cell content in South Asians: the key learnings.
Curr Opin Cardiol
September 2024
Purpose Of Review: We aim to provide a comprehensive examination of the literature linking elevated rates of cardiovascular disease (CVD) in individuals of South Asian ethnicity with the severity of circulating vascular regenerative cell exhaustion.
Recent Findings: Recent findings have demonstrated reduced bioavailability of pro-vascular progenitor cell subsets in individuals with T2D and obesity. Depletion of vascular regenerative cells in the bone marrow - coupled with decreased mobilization into circulation - can negatively impact the capacity for vascular repair and exacerbate CVD risk.