[Pharmacokinetic modeling in clinical practice: pefloxacin].

Pharmacokinetic modelling allows to set up a therapeutic plan for administering a drug. The advances of this procedure are particularly remarkable in drugs discharged by the liver. The principles of this approach are presented and illustrated on the treatment with pefloxacin.

[Pefloxacin in the treatment of recurrent urinary tract infections].

Thirty-seven patients with relapsing infections of the urinary tract were treated with pefloxacine, 400 mg/12 h for a period of 7-28 days. The clinical success of treatment was 100%, the bacteriological success 95%. Within 3-4 weeks after termination of treatment 63% of the patients did not develop a relapse, in particular those who did not have morphological changes of the kidneys.