Publications by authors named "A Krassioukov"
Making the Invisible Visible: Understanding Autonomic Dysfunctions Following Spinal Cord Injury.
Phys Med Rehabil Clin N Am
February 2025
Autonomic dysfunctions are a major challenge to individuals following spinal cord injury. Despite this, these consequences receive far less attention compared with motor recovery. This review will highlight the major autonomic dysfunctions following SCI predominantly based on our present understanding of the anatomy and physiology of autonomic control and available clinical data.
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- The study investigates the cardiovascular dysfunction caused by spinal cord injury (SCI) and assesses the efficacy of four neuroprotective agents in aiding cardiovascular recovery.
- Male Wistar rats were given spinal contusions and treated with Fluoxetine, Glyburide, Valproic acid, and Indomethacin, with outcomes measured through blood pressure changes, locomotor function, and lesion area.
- The results showed that Indomethacin and Valproic acid led to high mortality rates, while Fluoxetine and Glyburide were tolerated, but none of the treatments significantly improved blood pressure control or locomotor function compared to the control group.
Article Synopsis
- Cervical spinal cord injuries can cause low blood pressure and poor cardiovascular responses during exercise due to disrupted sympathetic function, impacting individuals' ability to perform physical activities.
- This study compared the effects of two stimulation methods (epidural and transcutaneous spinal cord stimulation) versus sham stimulation on cardiovascular responses and upper-body exercise performance in men with chronic spinal cord injuries.
- Results showed that the optimized stimulation improved blood pressure, cardiac contractility, and exercise endurance, suggesting both methods could help enhance exercise performance and reduce fatigue for those with spinal cord injuries.
Study Design: Secondary analysis of a clinical trial.
Objective: To assess the impact of 6 months of arm cycle ergometry training (ACET), or body weight-supported treadmill training (BWSTT), on autonomic cardiovascular responses to a laboratory sit-up test (SUT) in individuals with chronic (≥1-year post-injury) spinal cord injury (SCI).
Setting: Tertiary Rehabilitation Centre, Vancouver, Canada.
Bowel and Bladder Dysfunction after SCI: A Comparison between India and Canada.
Top Spinal Cord Inj Rehabil
August 2024
Background: The inclusion of people living with spinal cord injury (SCI) in research has allowed for an informed understanding of priorities of recovery of which bowel dysfunction and bladder dysfunction have been continuously identified. Research has also demonstrated the global disparities in SCI outcomes particularly when comparing high- and low-income countries. Currently, there is a lack of direct comparison between countries when assessing SCI outcomes.
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