Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study.

Background: The use of hydroxocobalamin has long been advocated for treating suspected cyanide poisoning after smoke inhalation. Intravenous hydroxocobalamin has however been shown to cause oxalate nephropathy in a single-center study. The impact of hydroxocobalamin on the risk of acute kidney injury (AKI) and survival after smoke inhalation in a multicenter setting remains unexplored.

The ETHICA study (part II): simulation study of determinants and variability of ICU physician decisions in patients aged 80 or over.

Purpose: To assess physician decisions about ICU admission for life-sustaining treatments (LSTs).

Methods: Observational simulation study of physician decisions for patients aged ≥80 years. Each patient was allocated at random to four physicians who made decisions based on actual bed availability and existence of an additional bed before and after obtaining information on patient preferences.

The ETHICA study (part I): elderly's thoughts about intensive care unit admission for life-sustaining treatments.

Purpose: To assess preferences among individuals aged ≥80 years for a future hypothetical critical illness requiring life-sustaining treatments.

Methods: Observational cohort study of consecutive community-dwelling elderly individuals previously hospitalised in medical or surgical wards and of volunteers residing in nursing homes or assisted-living facilities. The participants were interviewed at their place of residence after viewing films of scenarios involving the use of non-invasive mechanical ventilation (NIV), invasive mechanical ventilation (IMV), and renal replacement therapy after a period of invasive mechanical ventilation (RRT after IMV).