Pulmonary Adenocarcinoma with Enteric Differentiation without TTF-1 Expression Is a Very Rare Subtype with Limited Treatment Options and Poor Prognosis.

Introduction: Pulmonary adenocarcinoma with enteric differentiation (PAED) without thyroid transcription factor-1 (TTF-1) expression is an extremely rare variant of lung cancer. Due to its rarity, few clinicopathological and molecular studies have been performed on PAED, particularly in Caucasian patients. Therefore, it is necessary to obtain clinicopathological data of Caucasian PAED patients without TTF-1 expression, their systemic therapy options, and the efficacy of their systemic treatment.

[Respiratory response to inspiratory resistive load changes in patients with obstructive sleep apnea syndrome].

Patients with OSA have many episodes of increased airway resistance because of repeated collapses of upper airways during night. The aim of this work was to evaluate respiratory response during chemical stimulation without and with added inspiratory resistive load (10 cmH2O/L/sec). The studies were performed during quiet breathing with air and during hypercapnic and hypoxic rebreathing tests without and with inspiratory resistive loading in 23 obese (BMI = 34.

Respiratory responses to chemical stimulation in patients with obstructive sleep apnoea.

Chemical control of breathing in obstructive sleep apnoea (OSA) patients has been studied by many authors. The results of previous studies, especially those dealing with hypoxic drive, are discordant. Respiratory responses were studied during hypercapnic and hypoxic stimulation in a group of 37 normocapnic patients with OSA during wakefulness.

The susceptibility of gram-negative rods and their adaptive forms resistant to colistine to the bactericidal action of sera.

The susceptibility of Escherichia coli K1, Salmonella enteritidis, Salmonella typhimurium strains and their adaptative forms resistant to colistine (Colr forms) was compared with respect to their sensitivity to the bactericidal action of normal cord serum and normal bovine serum. It has been shown that the Colr forms are more susceptible to sera as compared to initial strains. The increase of sensitivity of the Colr forms is connected with structural changes within bacterial cell wall which is the target for complement as well as for colistine.

[Results of respiratory muscle training in patients with chronic obstructive lung diseases with a moderately severe course].

The aim of the study was to testify the effectiveness and acceptance of combination of the resistive inspiratory muscle training and the following walking training in 26 stable COPD pts with FEVI%VC about 50%. Measurements of inspiratory (MIP cm H20) and expiratory (MEP cm H20) muscle strength and also spirometric examinations two times before the training and one time after every month of observation were done. During first 3 months of the training inspiratory resistor (Pflex) was used.