Publications by authors named "A Korzon-Burakowska"
Review and Evaluation of European National Clinical Practice Guidelines for the Treatment and Management of Active Charcot Neuro-Osteoarthropathy in Diabetes Using the AGREE-II Tool Identifies an Absence of Evidence-Based Recommendations.
J Diabetes Res
June 2024
Charcot neuro-osteoarthropathy (CNO) is a rare but devastating complication of diabetes associated with high rates of morbidity; yet, many nonfoot specialists are unaware of it, resulting in missed and delayed diagnosis. Clinical practice guidelines (CPGs) have proven useful in improving quality of care and standardizing practice in diabetes and diabetic foot care. However, little is known about the consistency in recommendations for identification and management of active CNO.
View Article and Find Full Text PDFDiabetic foot ulcer (DFU) is one of the most common chronic complications of diabetes. This study aimed to assess the factors with an impact on the infection of diabetic foot ulcers by methicillin-resistant S. aureus and to evaluate the influence of methicillin resistance on the frequency of osteitis (based on classic X-ray images).
View Article and Find Full Text PDFArticle Synopsis
- Charcot neuroarthropathy is a progressive condition in diabetic patients that leads to bone destruction in the foot and joint disorganization.
- Current prevention and treatment lack effectiveness, and there's no reliable way to identify at-risk diabetic patients.
- The review explores the condition's history, symptoms, potential genetic markers, and recent research on monocyte-to-osteoclast differentiation in its development.
One of significant challenges faced by diabetologists, surgeons and orthopedists who care for patients with diabetic foot syndrome is early diagnosis and differentiation of bone structure abnormalities typical of these patients, i.e. osteitis and Charcot arthropathy.
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- Charcot arthropathy is a severe complication of diabetic foot syndrome that often results in limb amputation, and early diagnosis and preventive care are crucial since there is no cure.
- Diagnosis is challenging due to the disease's unclear clinical symptoms and the absence of specific molecular markers for early detection.
- Recent research highlights the OPG-RANKL-RANK pathway's role in bone metabolism and identifies specific SNPs in the OPG gene, suggesting their potential use as markers for Charcot arthropathy and providing insights into the disease's molecular mechanisms.