Publications by authors named "A Korosi"
Brain region and sex-dependent heterogeneity of PUFA/oxylipin profile, microglia morphology and their relationship.
Prostaglandins Leukot Essent Fatty Acids
December 2024
Lipid dyshomeostasis and neuroinflammation are key hallmarks of neuropsychiatric and neurodegenerative disorders, including major depressive disorder and Alzheimer's disease. In particular, polyunsaturated fatty acids (PUFAs) and their derivatives called oxylipins gained specific interest in this context, especially considering their capacity to orchestrate neuroinflammatory responses via direct modulation of microglia. The hippocampus and hypothalamus are crucial brain regions for regulating mood and cognition that are implicated in a variety of neuropsychiatric and neurodegenerative disorders and there is ample evidence for the sex-bias in risks for the development as well as sex-bias in the presentation of such psychiatric diseases, including the neuroinflammatory response.
View Article and Find Full Text PDFArticle Synopsis
- Maternal stress during the postpartum period affects the nutrient composition and microbiome of human milk (HM), potentially impacting early development and mental health outcomes for infants.
- A study involving high-stress (HS) and control groups analyzed HM microbiome changes, revealing distinct differences in bacterial composition, particularly showing HS mothers had altered levels of certain bacteria like reduced Streptococcus and increased Staphylococcus.
- The findings indicate a strong correlation between maternal stress and changes in the HM microbiome, suggesting these alterations could influence infant gut colonization and overall health, necessitating further research on their implications.
Article Synopsis
- Alzheimer's Disease is influenced by genetic, environmental, and lifestyle factors, including exercise, diet, education, and early life stress, which can affect its onset and progression.
- Recent research has identified crucial biological processes, like stress hormones and neuroinflammation, that may link early life stress to an increased risk of developing Alzheimer's Disease.
- Gaining insights into how early life experiences shape brain health could lead to new prevention and treatment strategies to counteract the impact of stress and reduce dementia risk.
Brain health is a pressing global concern. Poor diet quality is a recognized major environmental risk factor for brain disorders and one of the few that is modifiable. There is substantial evidence that nutrition impacts brain development and brain health across the life course.
View Article and Find Full Text PDFPrenatal adversity affects cognitive and brain aging. Both lipid and leptin concentrations may be involved. We investigated if prenatal undernutrition is associated with a specific blood lipid profile and/or leptin concentrations, and if these relate to cognitive function and brain aging.
View Article and Find Full Text PDF