Publications by authors named "A Korhonen"
Air pollution is a leading environmental health risk factor. The risk estimates, primarily based on air pollution epidemiology, are sensitive to exposure misclassification, which can result in underestimation. To address some of these challenges, our aim is to investigate how the length of the period over which the exposure is averaged, trends in long-term PM concentrations, and the seasonal variability are associated with each other.
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- The study examined long-term outcomes for women who experienced a maternal stroke, focusing on mortality, recovery, vocational status, and overall health compared to matched stroke-free controls.
- Out of 235 women with maternal strokes studied in Finland from 1987 to 2016, the mortality rate was significantly higher than controls (5.5% vs. 2.4%), but 90.3% of cases retained independence in daily activities after follow-up.
- Women who had a maternal stroke were less likely to be employed and more likely to be on pensions, while also facing higher rates of cardiovascular-related health issues compared to the control group.
Article Synopsis
- The study examines the use of intravenous thrombolysis (IVT) and endovascular thrombectomy for treating ischemic strokes in pregnant women, highlighting a lack of previous research in this area.
- Data was collected from national registers in Finland over nearly three decades, comparing the outcomes of 12 IVT-treated maternal stroke patients to a control group of young females with non-pregnancy-related strokes.
- Results indicate that while IVT-treated patients showed significant neurological improvement, their overall functional outcomes were less favorable compared to controls, suggesting that maternal strokes should not be dismissed from potential recanalization therapies.
Motivation: Scientific advances build on the findings of existing research. The 2001 publication of the human genome has led to the production of huge volumes of literature exploring the context-specific functions and interactions of genes. Technology is needed to perform large-scale text mining of research papers to extract the reported actions of genes in specific experimental contexts and cell states, such as cancer, thereby facilitating the design of new therapeutic strategies.
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