Publications by authors named "A Komori"
The relationship between nanoliposomal irinotecan/fluorouracil/leucovorin (NFF) treatment outcomes and neutropenia in patients with pancreatic cancer has not been thoroughly examined. Thus, we conducted a retrospective analysis of data from patients with pancreatic cancer who were treated with NFF to investigate this relationship. Neutropenia was assessed according to the Common Terminology Criteria for Adverse Events across three cutoffs: A (grade 0 versus grade 1-4), B (grades 0-1 versus 2-4), and C (grades 0-2 versus 3-4).
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- The study examined the prevalence and characteristics of MSI-high tumors in patients with metastatic or recurrent gastric cancer (GC) that had not yet undergone chemotherapy.
- MSI-high GC was found in 5.6% of patients, with higher prevalence in females, individuals aged 70 and older, tumors located in the lower stomach, HER2-negative cases, and patients without liver metastases.
- Understanding these MSI-high tumors can enhance clinical practices and inform future research targeting this specific subtype of GC.
Article Synopsis
- The study aimed to validate anti-integrin αvβ6 autoantibodies as a diagnostic biomarker for primary sclerosing cholangitis (PSC) using a new ELISA Kit across multiple hospitals.
- The research involved 81 PSC patients and 358 controls, finding a strong correlation between two testing methods and demonstrating high sensitivity (82.7%) and specificity (94.4%) for diagnosing PSC.
- The presence of these autoantibodies was particularly pronounced in PSC patients without inflammatory bowel disease, highlighting their potential as a reliable biomarker for PSC.
Patients with hard-to-treat autoimmune hepatitis (AIH) or primary biliary cholangitis (PBC) are defined a posteriori as those who do not show a sufficient response or are intolerant to pharmacological treatments, thus not achieving biochemical surrogate endpoints that are associated with long-term liver-related-event-free survival. The absence of a recently harmonized definition of 'complete biochemical response within 6 months (CBR≤6M)', which is defined as the normalization of serum transaminase and IgG levels below the upper limit of normal (ULN) at ≤6 months after treatment initiation is regarded as hard-to-treat AIH. The implementation of CBR≤6M, in turn, has been facilitating clinical trials, e.
View Article and Find Full Text PDFThis study aimed to test the effectiveness of Raman spectroscopy in the characterization of the degrees of physiological stress and virulence in clinical swab samples collected from patients affected by oral candidiasis. Raman experiments were conducted on a series of eight isolates, both in an as-collected state and after biofilm purification followed by 3 days of culture. The outputs were matched to optical microscopy observations and the results of conventional chromogenic medium assays.
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