Publications by authors named "A Kollias"
Although metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed nonalcoholic fatty liver disease, has become the most common chronic liver disorder, its complex pathophysiology has not been fully elucidated up to date. A correlation between elevated sympathetic activation and MASLD has been highlighted in recent preclinical and clinical studies. Furthermore, increased sympathetic activity has been associated with the main mechanisms involved in MASLD, such as lipid accumulation in the liver, insulin resistance, and metabolic dysregulation, while it has been also correlated with the progression of MASLD, leading to liver fibrosis.
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- - The study examined how effective and safe nifedipine GITS and ramipril are for treating hypertension in Chinese versus European patients through a post-hoc analysis of a multinational trial.
- - The research found that while both medications reduced blood pressure similarly across ethnic groups, ethnic differences impacted age, body mass index, and certain blood pressure measurements, and the response to treatment varied between the two groups.
- - The safety profiles noted significant differences, with fewer adverse events in Chinese patients taking nifedipine, while Europeans experienced more ankle edema with nifedipine and dry cough with ramipril.