Publications by authors named "A Koehn"
Background: Avascular osteonecrosis of the femoral head (AVN) often results in total hip arthroplasty (THA). The cause for increased THA revision rates among patients with AVN is not yet fully understood.
Purpose: To perform a comparative radiological analysis of implant integration between patients with AVN and osteoarthritis (OA).
Article Synopsis
- Congenital anomalies significantly contribute to infant mortality rates globally, and this study focuses on their prevalence and survival rates in Saxony-Anhalt, Germany.
- Data from 1,012 cases of nine major congenital anomalies were analyzed, revealing a prevalence range from 2.5 to 5.8 per 10,000, with a notable 1-year survival rate of 61.7% when including all pregnancy outcomes.
- Factors such as gestational age and birth weight were found to negatively impact survival, and the study highlights the importance of comprehensive data collection for accurate survival analysis.
Article Synopsis
- Sanfilippo type B is a serious condition caused by a genetic mutation affecting enzyme production, leading to harmful buildup of heparan sulfate in the brain, and requires effective enzyme delivery for treatment.
- In a phase I/II study with 22 patients, tralesinidase alfa was given via an intraventricular (i.c.v) route, demonstrating that a 300 mg dose is needed to normalize heparan sulfate levels and halt brain volume loss over 48 weeks.
- The study also found that treatment positively correlated with improvements in cognitive scores and changes in brain volume, indicating the potential effectiveness of tralesinidase alfa in managing Sanfilippo type B.