Publications by authors named "A Kocijancic"
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer that often goes undiagnosed until advanced stages, resulting in limited treatment options primarily focused on chemotherapy, which patients frequently build resistance to.
- The complexity of PDAC, characterized by genetic mutations and a challenging tumor microenvironment, makes it difficult to find innovative treatment solutions, highlighting the need for effective models to study these factors.
- Recent advancements in research models, such as organoids and 3D bioprinting, are providing valuable insights into PDAC biology and drug resistance, aiming to enhance therapeutic strategies and improve patient outcomes.
Article Synopsis
- Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis, primarily affecting glial cells and involving significant genetic and epigenetic alterations.
- Epigenetics involves reversible changes in gene expression without altering DNA sequences, making it a key area for potential cancer therapies targeting GBM.
- The review will explore the main epigenetic dysregulations in GBM, their impact on vital tumor pathways, and the role of non-coding RNAs, like miRNAs, in understanding tumor progression and improving diagnosis or prognosis.
Glioblastoma remains one of the most aggressive cancers of the brain, warranting new methods for early diagnosis and more efficient treatment options. Circular RNAs (circRNAs) are rather new entities with increased stability compared to their linear counterparts that interact with proteins and act as microRNA sponges, among other functions. Herein, we provide a critical overview of the recently described glioblastoma-related circRNAs in the literature, focusing on their roles on glioblastoma cancer cell proliferation, survival, migration, invasion and metastasis, metabolic reprogramming, and therapeutic resistance.
View Article and Find Full Text PDFAtrial fibrillation (AF) is associated with the development and progression of chronic kidney disease (CKD). This study evaluated the impact of long-term rhythm outcome after catheter ablation (CA) of AF on renal function. The study group included 169 consecutive patients (the mean age was 59.
View Article and Find Full Text PDFBackground: Late reconnections (LR) of pulmonary veins (PVs) after wide antral circumferential ablation (WACA) using point-to-point radiofrequency (RF) ablation are common. Lesion size index (LSI) is a novel marker of lesion quality proposed by Ensite Precision mapping system, expected to improve PV isolation durability. This study aimed to assess the durability of LSI-guided PVI and the risk factors for LR of PVs.
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