Publications by authors named "A Klingler"
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by type 2 (T2) inflammation. Recent studies, including our own, suggest that neutrophils are also elevated in T2 nasal polyps (NP) and that elevated neutrophils display an activated phenotype. However, the actual roles of neutrophils in NP pathogenesis in T2 CRSwNP are still largely unclear.
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- - The study evaluated the safety and effectiveness of a booster dose of VLA15, an investigational Lyme disease vaccine, after previously completing the primary vaccination series, as Lyme borreliosis cases are on the rise and effective vaccines are lacking.
- - Conducted as a randomized, placebo-controlled trial, the research involved healthy adults aged 18-65 from five US centers, who received either 135 μg or 180 μg of VLA15 or placebo over an 18-month period before the booster was administered.
- - Results focused on assessing the booster dose's immunogenicity and safety, with monitoring conducted by impartial groups to ensure accurate data collection, and the study is registered and completed under ClinicalTrials.gov (NCT
Background: Eosinophils are elusive cells involved in allergic inflammation. Single-cell RNA-sequencing (scRNA-seq) is an emerging approach to deeply characterize cellular properties, heterogeneity, and functionality.
Objectives: We sought to comprehensively characterize the transcriptome and biological functions of human eosinophils at a site of severe allergic inflammation in the esophagus (ie, eosinophilic esophagitis [EoE]).
Article Synopsis
- A new preventive vaccine for Lyme borreliosis, VLA15, targeting key Borrelia outer surface proteins, is being studied due to rising infection rates and the challenges in timely diagnosis and treatment.
- Two phase 2 clinical trials were conducted on healthy adults to determine the optimal vaccine dosage and schedule, with participants receiving varying dosages (90 μg, 135 μg, or 180 μg) via injections.
- The primary goal of the studies was to measure the vaccine's effectiveness based on the levels of specific antibodies (IgG) one month after the final dose, ensuring rigorous safety and randomization protocols throughout the trials.
Article Synopsis
- Chronic rhinosinusitis with nasal polyps (CRSwNP) involves complex inflammation, and the specific functions of eosinophils in this condition are not well understood.
- Researchers used single-cell RNA sequencing to analyze eosinophils in nasal polyp tissue from patients with CRSwNP, comparing them to control samples.
- The study identified a diverse range of eosinophil subtypes in nasal polyps, with certain genes related to inflammation and cell growth being significantly upregulated, suggesting their key role in CRSwNP pathology.