Publications by authors named "A KleinJan"
Indocyanine-enhanced mouse model of bleomycin-induced lung fibrosis with hallmarks of progressive emphysema.
Am J Physiol Lung Cell Mol Physiol
February 2023
The development of new drugs for idiopathic pulmonary fibrosis strongly relies on preclinical experimentation, which requires the continuous improvement of animal models and integration with in vivo imaging data. Here, we investigated the lung distribution of bleomycin (BLM) associated with the indocyanine green (ICG) dye by fluorescence imaging. A long-lasting lung retention (up to 21 days) was observed upon oropharyngeal aspiration (OA) of either ICG or BLM + ICG, with significantly more severe pulmonary fibrosis, accompanied by the progressive appearance of emphysema-like features, uniquely associated with the latter combination.
View Article and Find Full Text PDFOral enoximone allows the reduction and discontinuation of inhaled steroids and beta2 agonists in asthmatic children.
Int J Pediatr Adolesc Med
June 2022
Article Synopsis
- - Over the past 20 years, asthma treatments for both adults and children have seen minimal advancements, with inhaled corticosteroids (ICS) and β-2-mimetics remaining the primary options, despite the introduction of some new therapies.
- - Enoximone, a PDE3 inhibitor, previously used for severe asthma cases, was tested on over 70 patients (aged 0-77) and showed positive improvements in asthma symptoms, quality of life, and drug compliance, with minimal side effects.
- - Enoximone not only alleviated asthma symptoms but also appeared to reduce the severity of related conditions such as allergies and eczema, suggesting it could serve as a valuable alternative or supplement to existing asthma treatments,
We report a case of intestinal lesions in a patient with a history of lupus nephritis and renal transplantation. Biopsy revealed an EBV-driven post-transplant lymphoproliferative disease (PTLD). An EBV-driven PTLD is a major complication after renal transplantation and is an important differential diagnostic consideration in the follow-up of renal transplant recipients.
View Article and Find Full Text PDF