Publications by authors named "A Kladi"
Myotonic Dystrophies (DM, Dystrophia Myotonia) are autosomal dominant inherited myopathies with a high prevalence across different ethnic regions. Despite some differences, mainly due to the pattern of muscle involvement and the age of onset, both forms, DM1 and DM2, share many clinical and genetic similarities. In this study, we retrospectively analyzed the medical record files of 561 Greek patients, 434 with DM1 and 127 with DM2 diagnosed in two large academic centers between 1994-2020.
View Article and Find Full Text PDFBackground: Destination memory defined as the ability to remember to whom we addressed a piece of information is found to be impaired in normal aging. Theories of affect development and research findings have shown that emotional charging improves performance on memory tasks, and also that Mu rhythm is desynchronized as an index of mirror neuron activation during such tasks.
Objective: In this paper, we sought to investigate the differences in Mu rhythm during an emotional destination memory task, between younger and older adults.
Article Synopsis
- Emotion can help improve memory in older adults, but age may affect "destination memory," which is the ability to recall who we shared information with.
- A study with 16 older adults with mild cognitive impairment (MCI) and 16 healthy controls found no differences in performance on memory tasks, but differences in brain activity were notable, particularly in frontal and temporal regions.
- The MCI group showed a specific brain pattern of Mu enhancement linked to poorer memory scores, suggesting that although they performed similarly to healthy individuals, their brain function indicates early signs of cognitive decline.
Spinal and bulbar muscular atrophy (Kennedy's disease) has been associated with balance dysfunction and falls. However, postural control has not been studied quantitatively. Here, we quantified upright stance and aimed to disentangle the role of vestibular, proprioceptive and oculomotor deficits.
View Article and Find Full Text PDFPurpose: Τo evaluate the clinical relevance of CEACAM5mRNA-positive circulating tumor cells (CTCs) in patients with metastatic colorectal cancer (mCRC).
Methods: Peripheral blood was obtained from 436 patients with mCRC before the initiation of systemic therapy. A second sample was obtained on treatment assessment from 296 (67.