Publications by authors named "A Kivisaari"
Background: The incidence of epidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is increasing worldwide.
Objectives: To study the role of the complement classical pathway components C1q, C1r and C1s in the progression of cSCC.
Methods: The mRNA levels of C1Q subunits and C1R and C1S in cSCC cell lines, normal human epidermal keratinocytes, cSCC tumours in vivo and normal skin were analysed with quantitative real-time polymerase chain reaction.
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Inflammation is a typical feature in cSCC progression. Analysis of the expression of inflammasome components in cSCC cell lines and normal human epidermal keratinocytes revealed upregulation of the expression of AIM2 mRNA and protein in cSCC cells.
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- Cutaneous squamous cell carcinoma (cSCC) is an increasingly common skin cancer, and researchers studied the roles of two proteins, C3 and complement factor B (CFB), in its growth.
- The analysis showed that C3 and CFB were significantly more expressed in cSCC cells compared to normal skin cells, with stronger expression in more invasive forms of the cancer.
- Experiments indicated that reducing C3 and CFB levels slowed down the migration and growth of cSCC cells, suggesting that these proteins could be potential targets for treatment and markers for the disease.
Article Synopsis
- The incidence of cutaneous squamous cell carcinoma (cSCC) is rising, particularly affecting patients with metastatic disease, highlighting the need for molecular markers to predict aggressive tumor behavior.
- Researchers analyzed the expression of tight junction (TJ) components, specifically claudin-11, in primary cSCC cell lines and normal keratinocytes, finding elevated levels in primary cells but low in metastatic ones.
- Claudin-11's expression in cSCC is linked to the activity of p38δ MAPK, and its loss may serve as a biomarker indicating advanced disease, with implications for tumor invasion regulation.
Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and its incidence is increasing globally. Long noncoding RNAs (lncRNA) are involved in various biological processes, and their role in cancer progression is emerging. Whole transcriptome analysis of cSCC cells (n = 8) and normal human epidermal keratinocytes (n = 4) revealed overexpression of long intergenic ncRNA (LINC00162) in cSCC cells.
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