Publications by authors named "A Kirsten"
Article Synopsis
- COPD is a chronic inflammatory lung disease, and there's a need for new anti-inflammatory treatments, particularly those targeting the PI3K pathway, with CHF6523 being an inhaled PI3Kδ inhibitor showing promise in preliminary tests.
- The study involved 44 patients with stable COPD, using a randomized double-blind design with two treatment phases over 28 days each, to evaluate the safety, tolerability, and pharmacokinetics of CHF6523 compared to a placebo.
- Results indicated that CHF6523 effectively reduced a key inflammatory marker (PIP) by 29.7% from baseline, with pharmacokinetic data suggesting limited drug accumulation and quick absorption after inhalation.
Background: The single-inhaler triple combination of beclometasone dipropionate, formoterol fumarate, and glycopyrronium (BDP/FF/G) is available for maintenance therapy of chronic obstructive pulmonary disease (COPD). Cardinal features of COPD are lung hyperinflation and reduced exercise capacity. TRIFORCE aimed to evaluate the effect of BDP/FF/G on lung hyperinflation and exercise capacity in patients with COPD.
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- Researchers aimed to validate the Late-Life Function and Disability Instrument (LLFDI) for assessing disability and loss of function specifically in people with Chronic Obstructive Pulmonary Disease (COPD).
- The study involved 605 COPD patients from six European countries, analyzing LLFDI scores and their correlations with physical functioning, symptoms, and health status.
- Results showed moderate validation of the LLFDI across various domains, highlighting significant correlations with disease severity and functional limitations but suggesting adjustments for some subdomains.
The question whether interference with the ubiquitous splicing machinery can lead to cell-type specific perturbation of cellular function is addressed here by T cell specific ablation of the general U5 snRNP assembly factor CD2BP2/U5-52K. This protein defines the family of nuclear GYF domain containing proteins that are ubiquitously expressed in eukaryotes with essential functions ascribed to early embryogenesis and organ function. Abrogating CD2BP2/U5-52K in T cells, allows us to delineate the consequences of splicing machinery interferences for T cell development and function.
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