Publications by authors named "A Kilbey"
Effective antibody responses are essential to generate protective humoral immunity. Different inflammatory signals polarize T cells towards appropriate effector phenotypes during an infection or immunization. Th1 and Th2 cells have been associated with the polarization of humoral responses.
View Article and Find Full Text PDFIn mice, γδ-T lymphocytes that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage during thymic development. In the periphery, these cells play a critical role in host defense and anti-tumor immunity. Unlike αβ-T cells that rely on MHC-presented peptides to drive their terminal differentiation, it is unclear whether MHC-unrestricted γδ-T cells undergo further functional maturation after exiting the thymus.
View Article and Find Full Text PDFIntraepithelial lymphocytes (IEL) expressing γδ T-cell receptors (γδTCR) play key roles in elimination of colon cancer. However, the precise mechanisms by which progressing cancer cells evade immunosurveillance by these innate T cells are unknown. Here, we investigated how loss of the Apc tumor suppressor in gut tissue could enable nascent cancer cells to escape immunosurveillance by cytotoxic γδIELs.
View Article and Find Full Text PDFArticle Synopsis
- IL-17A-producing γδ T cells in mice mainly consist of two subclasses: Vγ6+ tissue-resident cells and Vγ4+ circulating cells, both of which show different characteristics in tumor conditions.
- Research using single-cell RNA sequencing revealed that Vγ6+ cells have high levels of PD-1, while Vγ4+ cells increase TIM-3 in response to specific tumor signals (IL-1β and IL-23).
- Blocking PD-1 or TIM-3 leads to an increase in these T cell populations in tumor-bearing mice, highlighting their role in developing resistance to immunotherapy in cancer therapies.
Article Synopsis
- - γδT cells are unique immune cells found in mucosal tissues that help monitor and maintain tissue health, as well as fight cancer by recognizing and killing stressed or cancerous cells via the NKG2D receptor.
- - Despite their known role in acting against tumors, new findings indicate that NKG2D actually regulates a group of γδT cells that promote tumor growth by producing IL-17A.
- - Research shows that removing the NKG2D gene reduces γδT cell levels in tumors and slows cancer progression, suggesting that in tumor environments with NKG2D ligands, these cells can accumulate and contribute to cancer advancement.